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In this work, a miniaturized, automated, and cost-effective ELISA device is designed and implemented, without the utilization of conventional techniques such as pipetting or microfluidic valve technologies. The device has dimensions of 24 cm × 19 cm × 14 cm and weighs <3 kg. The total hardware cost of the device is estimated to be approximately $1200, which can be further reduced through optimization during scale-up production. Three-dimensional printed disposable parts, including the reagent reservoir disk and the microfluidic connector, have also been developed. IL-6 is used as a model system to demonstrate how the device provides an ELISA measurement. The cost per test is estimated to be <$10. The compactness, automated operation, along with the cost-effectiveness of this ELISA device, makes it suitable for point-of-care applications in resource-limited regions. 

Aims.This study explores the metal enrichment signatures attributed to the first generation of stars (Pop III) in the Universe, focusing on the E-XQR-30 sample – a collection of 42 high signal-to-noise ratio spectra of quasi-stellar objects (QSOs) with emission redshifts ranging from 5.8 to 6.6. We aim to identify traces of Pop III metal enrichment by analyzing neutral gas in the interstellar medium of primordial galaxies and their satellite clumps, detected in absorption. Methods.To chase the chemical signature of Pop III stars, we studied metal absorption systems in the E-XQR-30 sample, selected through the detection of the neutral oxygen absorption line at 1302 Å. The O Iline is a reliable tracer of neutral hydrogen and allowed us to overcome the challenges posed by the Lyman-αforest’s increasing saturation at redshifts above ∼5 to identify damped Lyman-αsystems (DLAs). We detected and analyzed 29 O Isystems atz ≥ 5.4, differentiating between proximate DLAs (PDLAs) and intervening DLAs. Voigt function fits were applied to obtain ionic column densities, and relative chemical abundances were determined for 28 systems. These were then compared with the predictions of theoretical models. Results.Our findings expand the study of O Isystems atz ≥ 5.4 fourfold. No systematic differences were observed in the average chemical abundances between PDLAs and intervening DLAs. The chemical abundances in our sample align with literature systems atz >  4.5, suggesting a similar enrichment pattern for this class of absorption systems. A comparison between these DLA-analogs at 4.5 <  z <  6.5 with a sample of very metal-poor DLAs at 2 <  z <  4.5 shows in general similar average values for the relative abundances, with the exception of [C/O], [Si/Fe] and [Si/O] which are significantly larger for the high-zsample. Furthermore, the dispersion of the measurements significantly increases in the high-redshift bin. This increase is predicted by the theoretical models and indicates a potential retention of Pop III signatures in the probed gas. Conclusions.This work represents a significant advancement in the study of the chemical properties of highly neutral gas atz ≥ 5.4, shedding light on its potential association with the metal enrichment from Pop III stars. Future advancements in observational capabilities, specifically high-resolution spectrographs, are crucial for refining measurements and addressing current limitations in the study of these distant absorption systems. 

This study introduces novel constraints on the free streaming of thermal relic warm dark matter (WDM) from Lyman- $\alpha$forest flux power spectra. Our analysis utilizes a high resolution, high redshift sample of quasar spectra observed using the HIRES and UVES spectrographs ( $z=4.2–5.0$). We employ a Bayesian inference framework and a simulation-based likelihood that encompasses various parameters including the free streaming of dark matter, cosmological parameters, the thermal history of the intergalactic medium, and inhomogeneous reionization to establish lower limits on the mass of a thermal relic WDM particle of 5.7 keV (at 95% CL). This result surpasses previous limits from the Lyman- $\alpha$forest through reduction of the measured uncertainties due to a larger statistical sample and by measuring clustering to smaller scales ( $k_{\max }=0.2{\mathrm{km}}^{-1}\mathrm{s}$). The approximately two-fold improvement due to the expanded statistical sample suggests that the effectiveness of Lyman- $\alpha$forest constraints on WDM models at high redshifts are limited by the availability of high quality quasar spectra. Restricting the analysis to comparable scales and thermal history priors as in prior studies ( $k_{\max }<0.1{\mathrm{km}}^{-1}\mathrm{s}$) lowers the bound on the WDM mass to 4.1 keV. As the precision of the measurements increases, it becomes crucial to examine the instrumental and modeling systematics. On the modeling front, we argue that the impact of the thermal history uncertainty on the WDM particle mass constraint has diminished due to improved independent observations. At the smallest scales, the primary source of modeling systematic arises from the structure in the peculiar velocity of the intergalactic medium and inhomogeneous reionization. Published by the American Physical Society2024 

ABSTRACT Intervening metal absorbers in quasar spectra at z > 6 can be used as probes to study the chemical enrichment of the Universe during the Epoch of Reionization. This work presents the comoving line densities (dn/dX) of low-ionization absorbers, namely, Mg ii (2796 Å), C ii (1334 Å), and O  i (1302 Å) across 2 < z < 6 using the E-XQR-30 metal absorber catalogue prepared from 42 XSHOOTER quasar spectra at 5.8 < z < 6.6. Here, we analyse 280 Mg ii (1.9 < z < 6.4), 22 C ii (5.2 < z < 6.4), and 10 O i (5.3 < z < 6.4) intervening absorbers, thereby building up on previous studies with improved sensitivity of 50 per cent completeness at an equivalent width of W > 0.03 Å. For the first time, we present the comoving line densities of 131 weak (W < 0.3 Å) intervening Mg ii absorbers at 1.9 < z < 6.4 which exhibit constant evolution with redshift similar to medium (0.3 < W < 1.0 Å) absorbers. However, the cosmic mass density of Mg ii – dominated by strong Mg ii systems – traces the evolution of global star formation history from redshift 1.9 to 5.5. E-XQR-30 also increases the absorption path-length by a factor of 50 per cent for C ii and O i whose line densities show a rising trend towards z > 5, in agreement with previous works. In the context of a decline in the metal enrichment of the Universe at z > 5, the overall evolution in the incidence rates of absorption systems can be explained by a weak – possibly soft fluctuating – ultraviolet background. Our results, thereby, provide evidence for a late reionization continuing to occur in metal-enriched and therefore, biased regions in the Universe. 

Abstract The variations in Lyαforest opacity observed atz> 5.3 between lines of sight to different background quasars are too strong to be caused by fluctuations in the density field alone. The leading hypothesis for the cause of this excess variance is a late, ongoing reionization process at redshifts below six. Another model proposes strong ionizing background fluctuations coupled to a short, spatially varying mean free path of ionizing photons, without explicitly invoking incomplete reionization. With recent observations suggesting a short mean free path atz∼ 6, and a dramatic improvement inz> 5 Lyαforest data quality, we revisit this latter possibility. Here, we apply the likelihood-free inference technique of approximate Bayesian computation (ABC) to jointly constrain the hydrogen photoionization rate Γ_HIand the mean free path of ionizing photonsλ_mfpfrom the effective optical depth distributions atz= 5.0–6.1 from XQR-30. We find that the observations are well-described by fluctuating mean free path models with average mean free paths that are consistent with the steep trend implied by independent measurements atz∼ 5–6, with a concomitant rapid evolution of the photoionization rate. 

ABSTRACT We present the first observational measurements of the Lyman-α (Ly α) forest flux autocorrelation functions in ten redshift bins from 5.1 ≤ z ≤ 6.0. We use a sample of 35 quasar sightlines at z > 5.7 from the extended XQR-30 data set; these data have signal-to-noise ratios of >20 per spectral pixel. We carefully account for systematic errors in continuum reconstruction, instrumentation, and contamination by damped Ly α systems. With these measurements, we introduce software tools to generate autocorrelation function measurements from any simulation. Our measurements of the smallest bin of the autocorrelation function increase with redshift when normalizing by the mean flux, 〈F〉. This increase may come from decreasing 〈F〉 or increasing mean free path of hydrogen-ionizing photons, λmfp. Recent work has shown that the autocorrelation function from simulations at z > 5 is sensitive to λmfp, a quantity that contains vital information on the ending of reionization. For an initial comparison, we show our autocorrelation measurements with simulation models for recently measured λmfp values and find good agreements. Further work in modelling and understanding the covariance matrices of the data is necessary to get robust measurements of λmfp from this data. 

ABSTRACT We present the Sherwood–Relics simulations, a new suite of large cosmological hydrodynamical simulations aimed at modelling the intergalactic medium (IGM) during and after the cosmic reionization of hydrogen. The suite consists of over 200 simulations that cover a wide range of astrophysical and cosmological parameters. It also includes simulations that use a new lightweight hybrid scheme for treating radiative transfer effects. This scheme follows the spatial variations in the ionizing radiation field, as well as the associated fluctuations in IGM temperature and pressure smoothing. It is computationally much cheaper than full radiation hydrodynamics simulations, and circumvents the difficult task of calibrating a galaxy formation model to observational constraints on cosmic reionization. Using this hybrid technique, we study the spatial fluctuations in IGM properties that are seeded by patchy cosmic reionization. We investigate the relevant physical processes and assess their impact on the z > 4 Lyman-α forest. Our main findings are: (i) consistent with previous studies patchy reionization causes large-scale temperature fluctuations that persist well after the end of reionization, (ii) these increase the Lyman-α forest flux power spectrum on large scales, and (iii) result in a spatially varying pressure smoothing that correlates well with the local reionization redshift. (iv) Structures evaporated or puffed up by photoheating cause notable features in the Lyman-α forest, such as flat-bottom or double-dip absorption profiles. 

ABSTRACT Recent quasar absorption line observations suggest that reionization may end as late as $$z \approx 5.3$$. As a means to search for large neutral hydrogen islands at $$z\ \lt\ 6$$, we revisit long dark gaps in the Ly $$\beta$$ forest in Very Large Telescope/X-Shooter and Keck/Echellette Spectrograph and Imager quasar spectra. We stack the Ly $$\alpha$$ forest corresponding to both edges of these Ly $$\beta$$ dark gaps and identify a damping wing-like extended absorption profile. The average redshift of the stacked forest is $z=5.8$. By comparing these observations with reionization simulations, we infer that such a damping wing-like feature can be naturally explained if these gaps are at least partially created by neutral islands. Conversely, simulated dark gaps lacking neutral hydrogen struggle to replicate the observed damping wing features. Furthermore, this damping wing-like profile implies that the volume-averaged neutral hydrogen fraction must be $$\langle x_{\rm H\,{\small {I}}} \rangle \ge 6.1 \pm 3.9~{{\ \rm per\ cent}}$$ at $z = 5.8$. Our results offer robust evidence that reionization extends below $z=6$. 

ABSTRACT We measure the mean free path ($$\lambda _{\rm mfp,H\, \small {I}}$$), photoionization rate ($$\langle \Gamma _{\rm H\, \small {I}} \rangle$$), and neutral fraction ($$\langle f_{\rm H\, \small {I}} \rangle$$) of hydrogen in 12 redshift bins at 4.85 < z < 6.05 from a large sample of moderate resolution XShooter and ESI QSO absorption spectra. The fluctuations in ionizing radiation field are modelled by post-processing simulations from the Sherwood suite using our new code ‘EXtended reionization based on the Code for Ionization and Temperature Evolution’ (ex-cite). ex-cite uses efficient Octree summation for computing intergalactic medium attenuation and can generate large number of high resolution $$\Gamma _{\rm H\, \small {I}}$$ fluctuation models. Our simulation with ex-cite shows remarkable agreement with simulations performed with the radiative transfer code Aton and can recover the simulated parameters within 1σ uncertainty. We measure the three parameters by forward-modelling the  Lyα forest and comparing the effective optical depth ($$\tau _{\rm eff, H\, \small {I}}$$) distribution in simulations and observations. The final uncertainties in our measured parameters account for the uncertainties due to thermal parameters, modelling parameters, observational systematics, and cosmic variance. Our best-fitting parameters show significant evolution with redshift such that $$\lambda _{\rm mfp,H\, \small {I}}$$ and $$\langle f_{\rm H\, \small {I}} \rangle$$ decreases and increases by a factor ∼6 and ∼104, respectively from z ∼ 5 to z ∼ 6. By comparing our $$\lambda _{\rm mfp,H\, \small {I}}$$, $$\langle \Gamma _{\rm H\, \small {I}} \rangle$$ and $$\langle f_{\rm H\, \small {I}} \rangle$$ evolution with that in state-of-the-art Aton radiative transfer simulations and the Thesan and CoDa-III simulations, we find that our best-fitting parameter evolution is consistent with a model in which reionization completes by z ∼ 5.2. Our best-fitting model that matches the $$\tau _{\rm eff, H\, \small {I}}$$ distribution also reproduces the dark gap length distribution and transmission spike height distribution suggesting robustness and accuracy of our measured parameters. 

ABSTRACT Proximity zones of high-redshift quasars are unique probes of their central supermassive black holes as well as the intergalactic medium (IGM) in the last stages of reionization. We present 22 new measurements of proximity zones of quasars with redshifts between 5.8 and 6.6, using the enlarged XQR-30 sample of high-resolution, high-SNR quasar spectra. The quasars in our sample have ultraviolet magnitudes of M1450 ∼ −27 and black hole masses of 109–1010 M⊙. Our inferred proximity zone sizes are 2–7 physical Mpc, with a typical uncertainty of less than 0.5 physical Mpc, which, for the first time, also includes uncertainty in the quasar continuum. We find that the correlation between proximity zone sizes and the quasar redshift, luminosity, or black hole mass, indicates a large diversity of quasar lifetimes. Two of our proximity zone sizes are exceptionally small. The spectrum of one of these quasars, with z  = 6.02, displays, unusually for this redshift, damping wing absorption without any detectable metal lines, which could potentially originate from the IGM. The other quasar has a high-ionization absorber ∼0.5 pMpc from the edge of the proximity zone. This work increases the number of proximity zone measurements available in the last stages of cosmic reionization to 87. This data will lead to better constraints on quasar lifetimes and obscuration fractions at high redshift, that in turn will help probe the seed mass and formation redshift of supermassive black holes.